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Despite this rationale, ini-tial controlled studies attempting to treat adultswith ARDS with exogenous surfactants wereunsuccessful (Anzueto et al. In pediatric patients, acuterespiratory distress is a more rare syndrome withincidences ranging from 1.4 to 7.9 % (Yu et al.2009; Dahlem et al. As with any disease model, the intricate dif-ferences between mice and humans need to be taken into consideration
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